Neuronal antibodies
Paraneoplastic cerebellar degeneration (PCD) is a heterogeneous group of disorders characterised by subacute cerebellar ataxia, specific tumour types and (often) associated anti-neuronal antibodies (of which there have been 9 characterised.) Initial screen includes Yo and Ri; the following antibodies are available.
| Antibody | Staining pattern | Associated tumours |
|---|---|---|
| Yo (PCA-1) | Purkinje cell cytoplasm and axons | Ovary, breast |
| Ma (Ma1) | Neuronal nuclei | Various cancer |
| Ta (Ma2) | Neuronal nuclei, perikaryon | Testicular cancer |
| Hu (ANNA1) | Nuclei of both central and peripheral neurones | SCLC |
| Ri (ANNA2) | Nuclei of central neurones | Breast, SCLC, gynaecological |
| CV2/CRMP | Oligodendrocytes cytoplasm | SCLC, thymoma |
| Amphiphysin | Central presynaptic terminals | Breast cancer, SCLC |
Please include full clinical details to ensure the most appropriate antibodies are tested.
Negative
Record last updated
August 26, 2025
Sample Container
5ml RST Vacutainers (Rust top)
Sample Container
5ml SST Vacutainers (Gold / Yellow top)
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