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Anti-Phospholipase A2 Receptor Antibody (anit-PLA2R)

Category Immunology
Test background

The anti-PLA2R (IgG) antibody assay is a quantitative enzyme immunoassay (ELISA) for the in vitro measurement of IgG antibodies targeted against the M-type-phospholipase A2 receptor (PLA2R) on renal podocytes in patient sera.

Clinical Indications

The anti-PLA2R test is useful in the diagnosis and monitoring of primary membranous glomerulonephritis

Anti-PLA2R antibodies are positive in 75-80% of cases of primary membranous glomerulonephritis.

There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression

Reference range

<14 RU/ml (negative)

Sample & container required Serum - 5ml Gel SST (RUST TOP)
Sample volume Minimum 1ml Serum
Sample collection

Samples should be transported at room temperature to the laboratory within 2-3 days from collection

Transport storage Room temperature
Turnaround time 14 days

This test is currently unaccredited due to a recent change in platform (manual to automation).