Anti-Phospholipase A2 Receptor Antibody (anit-PLA2R)
| Category | Immunology |
|---|---|
| Test background |
The anti-PLA2R (IgG) antibody assay is a quantitative enzyme immunoassay (ELISA) for the in vitro measurement of IgG antibodies targeted against the M-type-phospholipase A2 receptor (PLA2R) on renal podocytes in patient sera. |
| Clinical Indications |
The anti-PLA2R test is useful in the diagnosis and monitoring of primary membranous glomerulonephritis Anti-PLA2R antibodies are positive in 75-80% of cases of primary membranous glomerulonephritis. There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression |
| Reference range | <14 RU/ml (negative) |
| Sample & container required | Serum - 5ml Gel SST (RUST TOP) |
| Sample volume | Minimum 1ml Serum |
| Sample collection | Samples should be transported at room temperature to the laboratory within 2-3 days from collection |
| Transport storage | Room temperature |
| Turnaround time | 14 days |
| Notes | This test is currently unaccredited due to a recent change in platform (manual to automation). |