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Beta-2-microglobulin (β2M)

Category Biochemistry >> Proteins
Test background

β2M is a component of the MHC class I molecule that is responsible for mediating antigen presentation to cytotoxic T cells and is ubiquitous to all cell types (with the exception of erythrocytes). Up-regulation of β2M is observed in haematological malignancy (principally MM) and may facilitate prognostic information as a function of deterioration in glomerular function.

Clinical Indications

Monitoring of established haematological malignancy

Reference range

1.2-2.4 mg/L

Sample & container required SST (gold top)
Sample volume 0.5 mL
Transport storage Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis. Sample can be sent by first class post.
Turnaround time 1 week

Grossly haemolysed samples are unsuitable for this assay.