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CK Isoenzymes (CKISO, CK Isoforms)

Category Biochemistry >> Proteins
Test background

Human enzyme creatine kinase is composed of two subunits, M (muscle) & B (brain) arranged into dimers giving rise to three possible isoenzymes: MM, MB & BB.

Clinical Indications

The primary use of CK isoenzyme analysis is the identification of Macro CK Type 1 (a CK–immunoglobulin complex) or Macro CK Type 2 (mitochondrial CK) in individuals with a persistently raised total CK without obvious heart or muscle disease. Although CKMB > 5 % may be indicative of acute myocardial infarction, Troponin is a sensitive and specific marker of cardiac damage and CK isoenzyme analysis is now not routinely indicated for this purpose.

Reference range

CK Isoenzymes is a semi-qualitative test with interpretation provided. Analysis identifies which isoenzyme(s) are responsible for the elevation in total CK as well as detection of type 1 or type 2 macro-CKs.
The relative contribution of each isoenzyme present is provided as part of the report.

Sample & container required Serum
Sample volume 100 µL (all samples require total CK measurement: if referring from another laboratory please ensure that there is sufficient sample or you have provided your laboratory result on the request form).
Transport storage Stable at 2-8°C  for 72 hours. Please freeze pending dispatch for analysis.
Sample can be sent by first class post.
Turnaround time 4-6 Weeks
Notes

Please include the Total CK result on the request if available.

Specimens containing inhibitors of CK activity e.g. heparin, EDTA, citrate, fluoride or iodoacetate are unsuitable.