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North West London Pathology > Tests > Complement, total classical pathway (THC)

Complement, total classical pathway (THC)

Category Immunology
Test background

The CH50 assay measures the ability of serum complement components to form membrane attack complex, which can be detected by ELISA.
C3 and C4 levels must also be requested.
The assay is used as a screening test for defects of individual components of the classical and terminal pathways. It should not be used for monitoring complement consumption, instead request C3 and C4 levels.
Clinical Indications

Suspected complement deficiency
Recurrent infections
Reference range

50-125 % of normal
Sample & container required RST (rust top) Separate and freeze immediately Transport frozen
Sample volume 5-10 mL (1 mL serum)
Turnaround time 21 days