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DNA double stranded antibodies, quantitative

Category Immunology
Test background

Detection and quantitation of DNA is useful in the diagnosis of SLE and is more specific than the antinuclear antibody test. It is positive in about 50 % of cases of SLE. Low titres of anti-dsDNA can be present in normal individuals, and in patients with Sjögren's syndrome, rheumatoid arthritis and other connective tissue and autoimmune disorders. The presence of anti-dsDNA tends to correlate with lupus nephritis, and the anti-dsDNA level often, but not always, correlates with disease activity in SLE.

Clinicial Indications

Diagnosis of SLE Monitoring of SLE

Reference range

<4 IU/mL
Indeterminate 5 – 10 IU/mL
Positive > 10 IU/mL

Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 14 days
Notes

This test is currently unaccredited due to a recent change in platform/assay.