DNA double stranded antibodies, quantitative
| Category | Immunology |
|---|---|
| Test background |
Detection and quantitation of DNA is useful in the diagnosis of SLE and is more specific than the antinuclear antibody test. It is positive in about 50 % of cases of SLE. Low titres of anti-dsDNA can be present in normal individuals, and in patients with Sjögren's syndrome, rheumatoid arthritis and other connective tissue and autoimmune disorders. The presence of anti-dsDNA tends to correlate with lupus nephritis, and the anti-dsDNA level often, but not always, correlates with disease activity in SLE. |
| Clinical Indications |
Diagnosis of SLE Monitoring of SLE |
| Reference range | <4 IU/mL |
| Sample & container required | RST (rust top) |
| Sample volume | 5-10 mL (1 mL serum) |
| Turnaround time | 14 days |
| Notes | This test is currently unaccredited due to a recent change in platform/assay. |