Skip to main content

Login to North West London Pathology – consumables service

If you need a new account or you have a query about your order, please telephone the pathology call centre on 0203 313 5353.

If you have forgotten your password you can reset this yourself. Please click here if you have forgotten your password.

Results Line and Enquiries

0203 313 5353

DNA double stranded antibodies, quantitative

Category Immunology
Test background

Detection and quantitation of DNA is useful in the diagnosis of SLE and is more specific than the antinuclear antibody test. It is positive in about 50 % of cases of SLE. Low titres of anti-dsDNA can be present in normal individuals, and in patients with Sjögren's syndrome, rheumatoid arthritis and other connective tissue and autoimmune disorders. The presence of anti-dsDNA tends to correlate with lupus nephritis, and the anti-dsDNA level often, but not always, correlates with disease activity in SLE.

Clinical Indications

Diagnosis of SLE Monitoring of SLE

Reference range

<4 IU/mL
Indeterminate 5 – 10 IU/mL
Positive > 10 IU/mL

Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 14 days

This test is currently unaccredited due to a recent change in platform/assay.