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Enterocyte antibodies

Category Immunology
Test background

Autoimmune enteropathy is an entity reported primarily in infancy, resulting in intractable diarrhoea and associated with small bowel villous atrophy and the presence of circulating enterocyte antibodies. It is a multisystem disorder with a response, in many cases, to immunosuppressive therapy.

Clinical Indications

Differential diagnosis of autoimmune enteropathy and refractory sprue (coeliac disease)
Severe villous atrophy non-refractive to dietary restriction with circulating gut autoantibodies and/or associated autoimmune conditions, with a lack of severe immunodeficiency

Reference range


Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 28 days

Not currently performed in house; this test is referred to the Protein Reference Unit, Sheffield.