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Mannose-binding lectin

Category Immunology
Test background

Although most individuals with mannose-binding lectin (MBL) deficiency are healthy, they have an increased susceptibility to certain illnesses. The deficiency has been reported to be particularly common in infants with recurrent respiratory tract infection, otitis media, and chronic diarrhoea. MBL deficiency is also associated with non-infectious diseases in adults, including SLE, rheumatoid arthritis, cystic fibrosis and common variable immunodeficiency.

Clinicial Indications

Recurrent pyogenic/pneumococcal infections in children.

Reference range

See report

Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 28 days
Notes

Not currently performed in house; this test is referred to the Protein Reference Unit, Sheffield.