Myeloperoxidase antibodies
| Category | Immunology |
|---|---|
| Test background |
p-ANCAs are directed against myeloperoxidase and are generally associated with microscopic polyangiitis (MPA), Churg-Strauss syndrome (CSS). See neutrophil cytoplasmic antibodies (ANCA). |
| Clinical Indications |
Skin rashes with or without pain (cutaneous vasculitis) Systemic vasculitis General (protean) symptoms, such as feeling unwell, weight loss, night sweats, joint pains Haematuria/proteinuria (kidney-associated) Haemoptysis, difficulty in breathing (lungs) Muscle weakness/numbness of extremities (microvascular) Abdominal pain (gut) In addition to acute heart and brain symptoms when these organs are implicated |
| Reference range | <3.5 IU/mL = Neg |
| Sample & container required | RST (rust top) |
| Sample volume | 5-10 mL (1 mL serum) |
| Turnaround time | 5 days |