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Salivary gland antibodies

Category Immunology
Test background

Antibodies to the epithelial cells of the salivary duct occur in 60 % of patients with Sjögren’s syndrome. Sjögren's syndrome is a systemic autoimmune disease in which immune cells attack and destroy the exocrine glands that produce tears and saliva. Sjögren's syndrome can exist as a disorder in its own right (primary Sjögren's syndrome) or it may develop years after the onset of an associated rheumatic disorder, such as rheumatoid arthritis, SLE, scleroderma, primary biliary cirrhosis, etc. (secondary Sjögren's syndrome).

Clinicial Indications

Differential diagnosis of primary or secondary Sjögren’s syndrome (in conjunction with rheumatoid factor, anti-centromere and antinuclear antibody assay (ANA-patterns SSA/Ro and SSB/La specifically).

Reference range

Negative

Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 28 days
Notes

Not currently performed in house; this test is referred to the Protein Reference Unit, Sheffield.