Scl-70 antibodies
| Category | Immunology |
|---|---|
| Test background |
This test is only performed if the antinuclear antibody (ANA) screen is positive. The ENA screen includes antibodies to RNP, Sm, SS-A, SS-B, Scl-70 and Jo-1. If the ENA screen is positive then individual specificities will be checked and subsequently confirmed by immunoblot assay. Antibodies to DNA-topoisomerase (Scl-70) are found in patients with scleroderma (~25 %) and are usually associated with the progressive systemic sclerosis subset. |
| Clinical Indications |
Scleroderma Systemic sclerosis |
| Reference range | Negative |
| Sample & container required | RST (rust top) |
| Sample volume | 5-10 mL (1 mL serum) |
| Turnaround time | 5 days |