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Vedolizumab Trough level

Category Immunology
Test background

Vedolizumab (Entyvio©) is a humanised IgG1 antibody which inhibits the action of the mucosal trafficking α4β7 integrin and prevents migration of inflammatory T cells to the gut. Vedolizumab levels are measured in serum taken from patients just before an infusion (trough) using an indirect ELISA coated with α4β7 integrin

Clinicial Indications

For the monitoring of drug trough levels in IBD patients treated with Vedolizumab

Reference range

Results are reported between 0.8 µg/ml and 144 µg/ml. In the induction phase of the Entyvio© clinical trials week 6 trough levels were higher in responders than non-responders and higher trough levels were associated with increased mucosal healing in UC patients.

Sample & container required Serum (rust top) vacutainer
Sample volume 0.5ml
Sample collection

Samples should be taken just before the next infusion of drug (trough)

Transport storage Transportation at room temperature/ first class post is adequate. Storage at 4 degrees or -20 for long term.
Turnaround time 4 weeks