Anti-Mϋllerian hormone (AMH)
| Category | Biochemistry >> Endocrinology | ||||||||||
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| Test background |
AMH can be used to assess ovarian reserve and has the advantage that, compared with FSH, inhibin A/B and ultrasound antral follicular count, levels are relatively unaffected by the menstrual cycle and typically show low intra-individual variation. With respect to Assisted Reproductive Technology (ART), AMH has been used to rationalise treatment regimes in controlled ovarian stimulation, thus reducing risk of hyper-stimulation (OHSS) and often reducing treatment costs. |
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| Clinical Indications |
Assessment of ovarian reserve and appropriate stimulation regimes in ART. Risk mitigation of OHSS in fertility treatment. Occasionally used in differential diagnosis and monitoring of ovarian tumours. |
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| Reference range | Adult males 10.2 – 82.8 pmol/L Adult females AMH levels decline with age and interpretation is therefore most appropriately made by the fertility specialist requesting the test and in conjunction with the antral follicle count.
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| Sample & container required | Serum (red top) or (gold top) or lithium heparin plasma (green top) | ||||||||||
| Sample volume | 0.5 mL | ||||||||||
| Transport storage | Please freeze pending dispatch for analysis. Send to lab frozen. | ||||||||||
| Turnaround time | 3 Days | ||||||||||
| Notes | Grossly haemolysed samples are unsuitable for this assay. **Biotin note removed as not relevant for newer reagent** |
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