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0203 313 5353

Immunology

Our Immunology department helps to diagnose patients with allergies, defective immune systems and autoimmune diseases. This includes testing for thyroid disease, coeliac disease and systemic lupus erythematosus (SLE). Immunology also performs tests which detect hidden tuberculosis (TB) infection, and there are numerous research programmes underway, looking at allergy, HIV infection, immune deficiency, vaccine responses and immune function.

Our Immunology department provides a molecular service and is working with suppliers to develop an extensive sequencing service to assist in disease monitoring and response to therapies.

Our Histocompatibility and Immunogenetics laboratory performs tissue typing and crossmatching for kidney and bone marrow transplant patients and donors. We test the blood of potential transplant recipients for antibodies and compare them with those of potential donors to avoid rejection of the organ. We also perform the HLA-B27 test to confirm a suspected diagnosis of ankylosing spondylitis or reactive arthritis.

This is a regional service, including out-of-hours donor typing, and we work closely with laboratories in other trusts to ensure the on-going support for transplant patients across the region. This extensive programme includes pre-and post-transplant testing, and monitoring of patients.

The clinical staff responsible for clinical advice, diagnostic and interpretative services are:

Immunology Lead: Dr Peter Kelleher B.A. M.B. B.Ch. B.A.O: University of Dublin. M.R.C.P. (Ireland) Ph.D. Pathology: Imperial College University of London FRCPath

Histocompatibility & Immunogenetics Director: Arthi Anand

Immunology test database

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Acetylcholine receptor (ACR) antibodies
Adrenal cortex antibodies
Allergen Specific IgE (Phadia Immunocap)
Anti-Phospholipase A2 Receptor Antibody (anit-PLA2R)
Anti-TNF drug levels Anti- TNF drug neutralising antibodies (Infliximab IFX, Adalimumab ADA, Etanercept ETA, Vedolizumab VEDL)
Antinuclear antibody screen
Aquaporin Antibody
Basal ganglia antibodies (ABGA)
Beta 2-glycoprotein 1 antibodies
C1Q antibodies
Cardiac muscle antibodies
Cardiolipin antibodies
Centromere antibodies
Complement C1 esterase inhibitor – antigenic
Complement C1 esterase inhibitor – functional
Complement C3 and C4 components
Complement C3 nephritic factor
Complement C3 nephritic factor (C3NF)
Complement genetics
Complement, total alternative pathway
Complement, total classical pathway (THC)
Cyclic citrullinated peptide (CCP) antibodies
DNA double stranded antibodies, quantitative
Encephalitis Antibodies
Endomysial IgA antibodies
Enterocyte antibodies
Extractable nuclear (ENA) antibodies
Factor H and factor I
GAD (glutamic acid decarboxylase) antibodies
Ganglioside antibodies
Gastric parietal cell antibodies
Glomerular basement membrane (GBM) antibodies
Haemophilus antibodies
Histone antibodies
HLA-B*27 Typing (B27)
HLA-B*57:01 (B57)
Immunoglobulin-g subclasses (IgG1-4)
Insulin antibodies
Intrinsic factor antibodies
Islet cell antibodies
Jo-1 antibodies
Liver autoantibodies immunoblot
Liver kidney microsomal antibodies
Liver kidney stomach set
Lymphocyte functions
Lymphocyte subsets
M-type-phospholipase A2 receptor (Anti-PLA2R)
Mannose-binding lectin
Mitochondrial antibodies
MuSK antibodies
Myelin sheath antibodies
Myeloperoxidase antibodies
Myositis antibodies
Neutrophil antibodies (granulocyte antibodies)
Neutrophil cytoplasmic antibodies
Neutrophil function
Ovarian antibodies
Parathyroid antibodies
Pneumococcal antibodies
Pneumococcal serotype
PR3 antibodies
Primary Immune Deficiency (PID) panel
QuantiFERON – TB Gold
Rheumatoid factor (RF)
Salivary gland antibodies
Scl-70 antibodies
Serum Tryptase
Skin antibodies – pemphigus and bullous pemphigoid
Smooth muscle antibodies
Striated muscle antibodies
T-cell activation markers
TB ELISPOT
Tetanus antibodies
Thyroid peroxidase (TPO) antibodies
Thyroid stimulating hormone receptor (TSHR) antibodies
Tissue transglutaminase antibodies
Total IgE
Vedolizumab Trough level
Voltage gated calcium
Acetylcholine receptor (ACR) antibodies
Adrenal cortex antibodies
Allergen Specific IgE (Phadia Immunocap)
Anti-Phospholipase A2 Receptor Antibody (anit-PLA2R)
Anti-TNF drug levels Anti- TNF drug neutralising antibodies (Infliximab IFX, Adalimumab ADA, Etanercept ETA, Vedolizumab VEDL)
Antinuclear antibody screen
Aquaporin Antibody
Basal ganglia antibodies (ABGA)
Beta 2-glycoprotein 1 antibodies
C1Q antibodies
Cardiac muscle antibodies
Cardiolipin antibodies
Centromere antibodies
Complement C1 esterase inhibitor – antigenic
Complement C1 esterase inhibitor – functional
Complement C3 and C4 components
Complement C3 nephritic factor
Complement C3 nephritic factor (C3NF)
Complement genetics
Complement, total alternative pathway
Complement, total classical pathway (THC)
Cyclic citrullinated peptide (CCP) antibodies
DNA double stranded antibodies, quantitative
Encephalitis Antibodies
Endomysial IgA antibodies
Enterocyte antibodies
Extractable nuclear (ENA) antibodies
Factor H and factor I
GAD (glutamic acid decarboxylase) antibodies
Ganglioside antibodies
Gastric parietal cell antibodies
Glomerular basement membrane (GBM) antibodies
Haemophilus antibodies
Histone antibodies
HLA-B*27 Typing (B27)
HLA-B*57:01 (B57)
Immunoglobulin-g subclasses (IgG1-4)
Insulin antibodies
Intrinsic factor antibodies
Islet cell antibodies
Jo-1 antibodies
Liver autoantibodies immunoblot
Liver kidney microsomal antibodies
Liver kidney stomach set
Lymphocyte functions
Lymphocyte subsets
M-type-phospholipase A2 receptor (Anti-PLA2R)
Mannose-binding lectin
Mitochondrial antibodies
MuSK antibodies
Myelin sheath antibodies
Myeloperoxidase antibodies
Myositis antibodies
Neutrophil antibodies (granulocyte antibodies)
Neutrophil cytoplasmic antibodies
Neutrophil function
Ovarian antibodies
Parathyroid antibodies
Pneumococcal antibodies
Pneumococcal serotype
PR3 antibodies
Primary Immune Deficiency (PID) panel
QuantiFERON – TB Gold
Rheumatoid factor (RF)
Salivary gland antibodies
Scl-70 antibodies
Serum Tryptase
Skin antibodies – pemphigus and bullous pemphigoid
Smooth muscle antibodies
Striated muscle antibodies
T-cell activation markers
TB ELISPOT
Tetanus antibodies
Thyroid peroxidase (TPO) antibodies
Thyroid stimulating hormone receptor (TSHR) antibodies
Tissue transglutaminase antibodies
Total IgE
Vedolizumab Trough level
Voltage gated calcium