Centromere antibodies
| Category | Immunology |
|---|---|
| Test background |
These antibodies are found in a sub-group of scleroderma patients with the limited cutaneous form of the disease or CREST syndrome (calcinosis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly and telangiectasia). It is also seen in patients with primary biliary cirrhosis (8-31 %). |
| Clinical Indications |
Symptoms associated with systemic sclerosis, including skin involvement, Raynaud's phenomenon and arthralgias. |
| Reference range | Negative |
| Sample & container required | RST (rust top) |
| Sample volume | 5-10 mL (1 mL serum) |
| Turnaround time | 4 days |
| Notes | This test is currently unaccredited due to a recent change in platform/assay. |