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Specialist Integrated Haematological Malignancy Diagnostic Service

Click here to download the request form for SIHMDS tests

Click here to download the request form for Pre-transplant chimerism tests

Click here to download the request form for Post-transplant chimerism tests

Royal Marsden Solid Tumour Request Forms:

Molecular Pathology

Haematological malignancies are a diverse group of cancers that affect the blood, bone marrow and lymphatic systems.

The Specialist Integrated Haematological Malignancy Diagnostic Service (SIHMDS), is a diagnostic service that includes immunophenotyping (flow cytometry), cytogenetics, and molecular genetics.

The molecular genetics laboratory offers a variety of tests to study a range of haematological malignancies which are essential for the diagnosis, prognosis and monitoring of disease. The tests provided are either for molecular diagnostics or minimal residual disease monitoring.

Click here to download the request form for SIHMDS tests


Cytogenetic investigations study haematological malignancies at a chromosomal level either my complete microscopic analysis (karyotyping) or using gene or chromosome-specific probes (fluorescence in-situ hybridization). Chromosome abnormalities play a central role in the diagnosis and monitoring of treatment for many haematological malignancies and some tumours of solid tissue. The observation of a chromosomally abnormal clone may be consistent with a neoplastic process, and can help to classify a malignancy and/or provide prognostic information. Once identified, chromosome abnormalities may also be used to monitor patients’ response to therapy. Cytogenetic analysis may also identify disease progression.

Click here to download the request form for cytogenetic investigations

The laboratory is UKAS accredited to ISO15189:2012


Immunophenotyping tests are used to diagnose and classify suspected haematological abnormalities involving white blood cells. This test is vital in supplementing tests undertaken in cytogenetics and histopathology to provide further information on cell type and maturation. This information guides clinicians in formulating specific and effective treatment plans.

The immunophenotyping laboratory performs flow cytometric analysis for a wide variety of disorders, including: acute myeloid leukaemia (AML) acute lymphoblastic leukaemia (ALL) myeloproliferative disorders (MPD) chronic lymphocytic leukaemia (CLL) myelodysplastic syndromes (MDS) aplastic anaemia and other pancytopenias plasma cell disorders lymphocytosis investigation of CSF samples or effusions investigation of paroxysmal nocturnal haemoglobinuria.

Click here to download the request form for Immunophenotyping

Immunophenotyping test database

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