FISH analysis for Chimerism analysis (XX/XY) Post-BMT
Category | Specialist Integrated Haematological Malignancy Diagnostic Service (SIHMDS) >> Cytogenetics |
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Test background |
FISH involves the application of fluorescent DNA probes specific to genes or genetic regions of interest that highlight abnormalities involving these regions. |
Clinical Indications |
In patients who have received sex-mismatched bone marrow transplants, X/Y FISH is a useful means of rapidly screening large numbers of bone marrow cells for the presence of host cells that may be a sign of engraftment failure or early relapse. |
Reference range | N/A |
Sample & container required | See notes section |
Sample volume | Samples would not be rejected on the basis of small volume, however, 5 mL is ideal. |
Turnaround time | Post treatment FISH analysis is treated as routine; 95% should be reported within 21 calendar days according to national guidelines. Please note however that the average turn around for X/Y FISH in our laboratory is approximately 4 days. |
Notes | Sample required: |