FISH analysis for Chronic Eosinophilic Leukaemia
|Category||Specialist Integrated Haematological Malignancy Diagnostic Service (SIHMDS) >> Cytogenetics|
FISH involves the application of fluorescent DNA probes specific to genes or genetic regions of interest that highlight abnormalities involving these regions.
Detection of the FIP1L1-PDGFRA fusion gene or the corresponding cryptic 4q12 deletion supports the diagnosis of chronic eosinophilic leukemia (CEL) in patients with chronic hypereosinophilia. This abnormality is not detectable by conventional cytogenetic analysis. In cases where the diagnosis is conventional cytogenetic analysis may also be performed.
|Sample & container required||See notes section|
|Sample volume||Samples would not be rejected on the basis of small volume, however, 5 mL is ideal.|
|Turnaround time||HES referrals are treated as routine; 95% should be reported within 21 calendar days according to national guidelines. Please note however that the average turn around for this category in our laboratory is approximately 4 days.|