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Tyrosine Kinase Domain Mutation Analysis

Category Specialist Integrated Haematological Malignancy Diagnostic Service (SIHMDS) >> Molecular Pathology
Test background

Mutations in the tyrosine kinase domain of BCR-ABL are the most common cause of resistance to the tyrosine kinase inhibitors (TKI) in CML patients. Therefore, early detection of these mutations will guide clinicians to a more appropriate course of treatment. Sanger sequencing can detect a range of mutations within the TK domain to the level of approximately 20%

Clinicial Indications

BCR-ABL1 positive patients that are relapsing or not responding to treatment.

Sample & container required 20 mL peripheral blood or 3-5.0 mL bone marrow in EDTA (lavender top); 25uL of cDNA.
Transport storage Samples must be less than 72 hours old upon receipt within the laboratory. Therefore, samples received after 3pm on a Friday will be rejected (unless they were taken on the same day).
Turnaround time 20 working days