Skip to main content

Login to North West London Pathology – consumables service

If you need a new account or you have a query about your order, please telephone the pathology call centre on 0203 313 5353.

If you have forgotten your password you can reset this yourself. Please click here if you have forgotten your password.

Results Line and Enquiries

0203 313 5353

Tyrosine Kinase Domain Mutation Analysis

Category Specialist Integrated Haematological Malignancy Diagnostic Service (SIHMDS) >> Molecular Pathology
Test background

Mutations in the tyrosine kinase domain of BCR-ABL are the most common cause of resistance to the tyrosine kinase inhibitors (TKI) in CML patients. Therefore, early detection of these mutations will guide clinicians to a more appropriate course of treatment. Sanger sequencing can detect a range of mutations within the TK domain to the level of approximately 20%

Clinical Indications

BCR-ABL1 positive patients that are relapsing or not responding to treatment.

Sample & container required 20 mL peripheral blood or 3-5.0 mL bone marrow in EDTA (lavender top); 25uL of cDNA.
Transport storage Samples must be less than 72 hours old upon receipt within the laboratory. Therefore, samples received after 3pm on a Friday will be rejected (unless they were taken on the same day).
Turnaround time 20 working days