Jo-1 antibodies
| Category | Immunology |
|---|---|
| Test background |
This test is only performed if the antinuclear antibody (ANA) screen is positive. The ENA screen includes antibodies to RNP, Sm, SS-A, SS-B, Scl-70 and Jo-1. If the ENA screen is positive then individual specificities will be checked and subsequently confirmed by immunoblot assay. Jo-1 antibodies are detected in patients with myositis, especially in combination with pulmonary fibrosis. |
| Clinical Indications |
Suspected autoimmune-mediated connective tissue disorders Suspected myositis |
| Reference range | Negative |
| Sample & container required | RST (rust top) |
| Sample volume | 5-10 mL (1 mL serum) |
| Turnaround time | 14 days |
| Notes | This test is currently unaccredited due to a recent change in platform/assay. |