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Jo-1 antibodies

Category Immunology
Test background

This test is only performed if the antinuclear antibody (ANA) screen is positive. The ENA screen includes antibodies to RNP, Sm, SS-A, SS-B, Scl-70 and Jo-1. If the ENA screen is positive then individual specificities will be checked and subsequently confirmed by immunoblot assay. Jo-1 antibodies are detected in patients with myositis, especially in combination with pulmonary fibrosis.

Clinicial Indications

Suspected autoimmune-mediated connective tissue disorders Suspected myositis

Reference range

Negative

Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 14 days
Notes

This test is currently unaccredited due to a recent change in platform/assay.