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Adrenal cortex antibodies

Category Immunology
Test background

Anti-adrenal antibody results are positive in 60-70 % of patients with idiopathic Addison's disease. Antibodies against adrenal cortex are associated with primary adrenal failure in up to 50 % of patients with Addisonian adrenal insufficiency. Positive antibodies can, however, be an incidental finding or predate the development of hypoadrenalism. Anti-adrenal antibodies are also present in 28 % of patients with idiopathic hypothyroidism and 7 % of patients with Hashimoto's disease. Positive antibodies may also be associated with gonadal failure.

Clinical Indications

Raised titres in adrenocortical insufficiency due to an autoimmune disorder (Addison's Disease).

Reference range


Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 14 days

This test is currently unaccredited due to a recent change in platform.