Skip to main content

Login to North West London Pathology – consumables service

If you need a new account or you have a query about your order, please telephone the pathology call centre on 0203 313 5353.

If you have forgotten your password you can reset this yourself. Please click here if you have forgotten your password.

Results Line and Enquiries

0203 313 5353

Adrenal cortex antibodies

Category Immunology
Test background

Antibodies targeting the steroid producing cells of the adrenal cortex, ovaries and testes are found in around 80% of patients with Addison’s disease and are also seen in APS type I (also known as APECED- autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy), APS type II and premature ovarian or testicular failure. These antibodies are directed against three p450 cytochrome enzymes; 21α-hydroxylase (P450c21), 17α-hydroxylase (P450c17) and cholesterol desmolase (P450scc). New positive patients will be further screened for autoimmune liver and thyroid disease (LKS screen and TPO IgG) and antibodies associated with T1DM (IA2 and GAD IgG).

This test is performed by indirect immunofluorescence on primate triple (adrenal/testes/ovary) tissue sections.

Clinical Indications

Primary adrenal insufficiency/Addison’s disease
Autoimmune polyendocrinopathies
Premature ovarian or testicular failure (<40 years of age) Screening for adrenal disease in patients with T1DM or coeliac disease

Reference range


Sample & container required Serum (rust top RST tube)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 14 days