Intrinsic factor antibodies
| Category | Immunology |
|---|---|
| Test background |
Antibodies against intrinsic factor are present in 50-60 % of patients with pernicious anaemia. Their presence may pre-date the development of B12 deficiency. It is recommended to also check vitamin B12 levels. |
| Clinical Indications |
Differential diagnosis of pernicious anaemia (autoimmune causes are not refractory to dietary B12 supplementation). |
| Reference range | Negative |
| Sample & container required | RST (rust top) |
| Sample volume | 5-10 mL (1 mL serum) |
| Turnaround time | 14 days |
| Notes | Due to a change in platform, the laboratory is not currently accredited for this test. |