Acetylcholine receptor (ACR) antibodies
The most sensitive and specific test for myasthenia gravis is the presence of ACR. Myasthenia gravis is a neuromuscular disorder characterised by weakness and fatigability of skeletal muscles. The aetiology involves a numerical decrease in the number of available acetylcholine receptors at the neuromuscular junctions due to an antibody-mediated autoimmune attack. Not all patients who have myasthenia gravis have positive ACR titres. ACR antibodies are seen in 45 % to 65 % of patients with ocular myasthenia and in approximately 90 % of patients with generalised myasthenia gravis. The degree of 'positivity' for the test results does not correlate with the severity of disease.
Degenerative neuromuscular disease Respiratory crises Dysphagia Facial weakness
0-5 x 10-10 mol
|Sample & container required||RST (rust top)|
|Sample volume||5-10 mL (1 mL serum)|
|Turnaround time||28 days|
Not currently performed in house; this test is referred to the Immunology Department at Oxford.