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Complement C1Q antibodies

Category Immunology
Test background

C1q is a sub compartment of the initiating C1 complex of the classical pathway of complement activation. Antibodies to C1q are found in hypocomplementemic urticarial vasculitis syndrome (HUVS), infection associated vasculitis and in a variety of autoimmune diseases such as rheumatoid vasculitis, SLE, polyarteritis nodosa, giant cell arteritis, Behcet’s disease and cryoglobulinaemia. In lupus nephritis C1q antibody titres correlate with disease activity.

This test is performed by ELISA

Clinical Indications

Diagnosis of HUVS
Monitoring of lupus nephritis

Reference range

0-10 U/ml
Reference ranges are manufacturer derived and were verified in house

Sample & container required Serum (rust top RST tube)
Sample volume 5-10 mL blood (1 mL serum)
Turnaround time 21 days

Not routinely available. Please discuss with lab prior to taking sample.