Glomerular basement membrane (GBM) antibodies
| Category | Immunology | ||||||
|---|---|---|---|---|---|---|---|
| Test background |
Glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane. The target antigen is the alpha-3 chain of type IV collagen. The clinical syndrome encompasses a spectrum from mild or no renal involvement to a rapidly progressive glomerulonephritis. Significant proportions of patients develop pulmonary haemorrhage, and most individuals have signs of a generalised systemic illness. The combination of glomerulonephritis and pulmonary haemorrhage has been commonly referred to as Goodpasture’s syndrome. These antibodies are found in patients with Goodpasture’s syndrome (>90 % sensitivity). |
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| Clinical Indications |
Acute renal failure |
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| Reference range |
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| Sample & container required | RST (rust top) | ||||||
| Sample volume | 5 -10 mL (1 mL serum) | ||||||
| Turnaround time | 5 days |