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Glomerular basement membrane (GBM) antibodies

Category Immunology
Test background

Glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane. The target antigen is the alpha-3 chain of type IV collagen. The clinical syndrome encompasses a spectrum from mild or no renal involvement to a rapidly progressive glomerulonephritis. Significant proportions of patients develop pulmonary haemorrhage, and most individuals have signs of a generalised systemic illness. The combination of glomerulonephritis and pulmonary haemorrhage has been commonly referred to as Goodpasture’s syndrome. These antibodies are found in patients with Goodpasture’s syndrome (>90 % sensitivity).

Clinicial Indications

Acute renal failure
Deteriorating renal function
Blood in urine (haematuria) and/or blood in sputum (haemoptysis)
Pulmonary haemorrhage
Vasculitis

Reference range
<7 U/mL Negative
7 – 10 U/mL Equivocal
>10 U/mL Positive

 

Sample & container required RST (rust top)
Sample volume 5 -10 mL (1 mL serum)
Turnaround time 5 days