Skip to main content

Login to North West London Pathology – consumables service

If you need a new account or you have a query about your order, please telephone the pathology call centre on 0203 313 5353.

If you have forgotten your password you can reset this yourself. Please click here if you have forgotten your password.

Results Line and Enquiries

0203 313 5353

Glomerular basement membrane (GBM) antibodies

Category Immunology
Test background

Glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane. The target antigen is the alpha-3 chain of type IV collagen. The clinical syndrome encompasses a spectrum from mild or no renal involvement to a rapidly progressive glomerulonephritis. Significant proportions of patients develop pulmonary haemorrhage, and most individuals have signs of a generalised systemic illness. The combination of glomerulonephritis and pulmonary haemorrhage has been commonly referred to as Goodpasture’s syndrome. These antibodies are found in patients with Goodpasture’s syndrome (>90 % sensitivity).

Clinical Indications

Acute renal failure
Deteriorating renal function
Blood in urine (haematuria) and/or blood in sputum (haemoptysis)
Pulmonary haemorrhage

Reference range
<7 U/mL Negative
7 – 10 U/mL Equivocal
>10 U/mL Positive


Sample & container required RST (rust top)
Sample volume 5 -10 mL (1 mL serum)
Turnaround time 5 days