Glomerular basement membrane (GBM) antibodies
Glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane. The target antigen is the alpha-3 chain of type IV collagen. The clinical syndrome encompasses a spectrum from mild or no renal involvement to a rapidly progressive glomerulonephritis. Significant proportions of patients develop pulmonary haemorrhage, and most individuals have signs of a generalised systemic illness. The combination of glomerulonephritis and pulmonary haemorrhage has been commonly referred to as Goodpasture’s syndrome. These antibodies are found in patients with Goodpasture’s syndrome (>90 % sensitivity).
Acute renal failure
|Sample & container required||RST (rust top)|
|Sample volume||5 -10 mL (1 mL serum)|
|Turnaround time||5 days|