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MuSK antibodies

Category Immunology
Test background

Antibodies to the muscle-specific receptor tyrosine kinase are involved in the pathogenesis of acetylcholine receptor (ACR) antibody-negative myasthenia gravis. Testing for these antibodies should be considered in the 20 % of patients with clinical symptoms of myasthenia gravis who do not demonstrate antibodies to the ACR.

Clinical Indications

Diagnosis of myasthenia gravis with or without equivocal anti-AChR findings

Reference range

Negative

Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 28 days
Notes

Not currently performed in house; this test is referred to the Department of Immunology at the Churchill Hospital in Oxford.