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ENA (Extractable nuclear antigen) antibodies

Category Immunology
Test background

This test detects the most common nuclear and cytoplasmic IgG antibodies found in connective tissue disease. ENA are useful in classifying clinical subsets of connective tissue diseases. The ENA panel is tested following a positive ANA or CTD screen by a multiplex magnetic bead based immunoassay and includes Ro52, Ro60, SSB/La, Sm, RNP, Ribosomal P, Jo-1, Scl-70 (topoisomerase 1) and centromere B antibodies.

Clinical Indications

Suspected autoimmune-mediated connective tissue disorders

Reference range

Negative <1.0 antibody index (range derived by manufacturer and verified in house)

Sample & container required Serum (RST rust top)
Sample volume 5-10 mL blood (1 mL serum)
Turnaround time 10 days screen