Mitochondrial antibodies
| Category | Immunology |
|---|---|
| Test background |
Anti-mitochondrial antibodies (AMA), which are directed against components of mitochondrial dehydrogenase complexes, are detected by indirect immunofluorescence using mouse liver/kidney/stomach (LKS) substrate. Positive results are then tested by liver immunoblot for confirmation. |
| Clinical Indications |
Mitochondrial antibodies are associated with primary biliary cirrhosis AMA are also detected in patients with chronic hepatitis C infection and systemic sclerosis |
| Reference range | Negative |
| Sample & container required | RST (rust top) |
| Sample volume | 5-10 mL (1 mL serum) |
| Turnaround time | 7 days |
| Notes | This test is currently unaccredited due to a recent change in platform. |