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Mitochondrial antibodies

Category Immunology
Test background

Anti-mitochondrial antibodies (AMA), which are directed against components of mitochondrial dehydrogenase complexes, are detected by indirect immunofluorescence using mouse liver/kidney/stomach (LKS) substrate. Positive results are then tested by liver immunoblot for confirmation.

Clinicial Indications

Mitochondrial antibodies are associated with primary biliary cirrhosis AMA are also detected in patients with chronic hepatitis C infection and systemic sclerosis

Reference range

Negative

Sample & container required RST (rust top)
Sample volume 5-10 mL (1 mL serum)
Turnaround time 7 days
Notes

This test is currently unaccredited due to a recent change in platform.