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Haemophilus type b (Hib) antibodies

Category Immunology
Test background

This test measures IgG antibody levels to Haemophilus influenzae type b (Hib) for the assessment of the T cell dependent specific immune response to the conjugate Hib vaccine.

The Hib vaccine is part of the infant 6 in 1 vaccine given at 8, 12, and 16 weeks old, followed by a 4th Hib booster at age 1 year. In adults the Hib vaccine is no longer recommended in those at risk of invasive disease (asplenia, functional hyposlenism, classical complement deficiency) due to the successful childhood vaccination programme and the low risk of Hib disease

The laboratory recommends this test only as a third line screen for patients with recurrent invasive bacterial infections, following serum immunoglobulins, tetanus IgG levels and pneumococcal IgG serotypes.

Clinical Indications

Recurrent invasive bacterial disease

Reference range

0.15 µg/L minimum protective level
1 µg /L optimum protective level
Reference ranges verified by referral laboratory

Sample & container required Serum RST (rust top)
Sample volume 5-10 mL blood (1 mL serum)
Turnaround time 28 days

Not currently performed in house; this test is performed by ELISA at OUH Oxford Immunology Laboratory