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Neuromyelitis optica/NMO (Aquaporin 4) Antibody

Category Immunology
Test background

Aquaporin 4 antibodies are found in >80% of patients with neuromyelitis optica (NMO) and 50% of patients with longitudinally extensive transverse myelitis. NMO antibodies are not usually found in optic neuritis without spinal cord involvement.

Clinical Indications

NMO, myelitis

Reference range


Sample & container required Serum (rust top RST tube)
Sample volume 5-10 mL blood (1 mL serum)
Turnaround time 28 days

This test is a fixed cell indirect immunofluorescence method performed at Neuroimmunology, Queens Square.