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Endomysial IgA antibodies

Category Immunology
Test background

The endomysium is the thin layer of the connective tissue surrounding the smooth and striated muscles fibres of tissue.

Endomysial IgA antibodies are used to confirm coeliac disease or dermatitis herpetiformis in patients with tissue transglutaminase IgA antibodies (TTGA). Endomysial antibodies correlate well with TTGA and will decrease with adherence to a gluten-free diet.

This assay is performed by indirect immunofluorescence only on patients with a positive TTG IgA result. For coeliac disease screening please see Coeliac screen/TTG IgA.

Clinical Indications

Confirmatory test following a positive TTG IgA result

Reference range


Sample & container required Serum (RST rust top)
Sample volume 5-10 mL blood (1 mL serum)
Turnaround time 14 days

This test is currently unaccredited due to a recent change in platform.