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Striated (skeletal) muscle antibodies

Category Immunology
Test background

Antibodies against skeletal muscle are directed against the protein titin and the ryanomycin receptor. They are found in a proportion of patients with myasthenia gravis (MG), and most MG patients with thymoma. Presence of these antibodies in thymoma patients predicts the risk of myasthenia and recurrence of thymoma.
These antibodies may also be detected in patients with Lambert-Eaton myasthenic syndrome (LES), small cell lung carcinoma (SCLC), breast carcinoma, patients treated with D-penicillamine, bone marrow transplant recipients with graft-versus-host disease, and autoimmune liver disorders.

This test is performed by indirect immunofluorescence on primate striated muscle tissue sections.

Clinical Indications

Limited clinical value, myasthenia with thymoma

Reference range


Sample & container required Serum (RST rust top)
Sample volume 5-10 mL blood (1 mL serum)
Turnaround time 28 days

Not currently performed in house; this test is referred to the Protein Reference Unit (PRU), Sheffield.