Striated (skeletal) muscle antibodies
Antibodies against skeletal muscle are directed against the protein titin and the ryanomycin receptor. They are found in a proportion of patients with myasthenia gravis (MG), and most MG patients with thymoma. Presence of these antibodies in thymoma patients predicts the risk of myasthenia and recurrence of thymoma.
This test is performed by indirect immunofluorescence on primate striated muscle tissue sections.
Limited clinical value, myasthenia with thymoma
|Sample & container required
|Serum (RST rust top)
|5-10 mL blood (1 mL serum)
Not currently performed in house; this test is referred to the Protein Reference Unit (PRU), Sheffield.