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11-Deoxycortisol (11DOC)

Category Biochemistry
Test background

11DOC and 11-deoxycorticosterone accumulate in the presence of a functional or cumulative 11 hydroxylase deficiency a cause of congenital adrenal hyperplasia (CAH). This is one of the less common presentations of CAH. Measured also in the overnight metyrapone test for assessment of hypoadrenalism.

Clinical Indications

Clinical picture of CAH with any of the following: overnight metyrapone test, hypervolaemic hypernatraemia with or without hypertension or hypokalaemia

Reference range

See report

Sample & container required Serum (red top)
Sample volume 0.5 mL
Turnaround time Up to 6 weeks

17α-hydroxyprogesterone should be measured first. Not currently performed in house; this is a referred test.