11-Deoxycortisol (11DOC)
| Category | Biochemistry |
|---|---|
| Test background |
11DOC and 11-deoxycorticosterone accumulate in the presence of a functional or cumulative 11 hydroxylase deficiency a cause of congenital adrenal hyperplasia (CAH). This is one of the less common presentations of CAH. Measured also in the overnight metyrapone test for assessment of hypoadrenalism. |
| Clinical Indications |
Clinical picture of CAH with any of the following: overnight metyrapone test, hypervolaemic hypernatraemia with or without hypertension or hypokalaemia |
| Reference range | See report |
| Sample & container required | Serum (red top) |
| Sample volume | 0.5 mL |
| Turnaround time | Up to 6 weeks |
| Notes | 17α-hydroxyprogesterone should be measured first. Not currently performed in house; this is a referred test. |