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17α-Hydroxyprogesterone (17OHP)

Category Biochemistry >> Endocrinology
Test background

17OHP is a precursor of cortisol, the major glucocorticoid synthesised in the adrenal cortex. Congenital adrenal hyperplasia (CAH) results in excessive ACTH secretion due to impairment in the synthesis of cortisol. A variety of enzyme defects in the pathway to cortisol synthesis have been identified, of which the most common is a 21-hydroxylase deficiency; 17OHP is the substrate for this enzyme. The serum 17OHP levels are significantly elevated in this condition.

Clinicial Indications

Ambiguous neonatal genitalia (female infants) ’Salt-wasting’ clinical symptoms (dehydration, vomiting, listlessness) Precociousness or failure of puberty Virilisation

Reference range
0-3 months: <10nmol/L
3 months-5 years: 0-2.5 nmol/L
5-11 years: 0-3.0 nmol/L
Over 11 years: <9.6 nmol/L

 

Sample & container required Serum (red top)
Sample volume 0.5 mL
Transport storage Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis. Sample can be sent by first class post.
Turnaround time 10 days
Notes

Grossly haemolysed samples are unsuitable for this assay.