|Category||Biochemistry >> Endocrinology|
17OHP is a precursor of cortisol, the major glucocorticoid synthesised in the adrenal cortex. Congenital adrenal hyperplasia (CAH) results in excessive ACTH secretion due to impairment in the synthesis of cortisol. A variety of enzyme defects in the pathway to cortisol synthesis have been identified, of which the most common is a 21-hydroxylase deficiency; 17OHP is the substrate for this enzyme. The serum 17OHP levels are significantly elevated in this condition.
Ambiguous neonatal genitalia (female infants) ’Salt-wasting’ clinical symptoms (dehydration, vomiting, listlessness) Precociousness or failure of puberty Virilisation
|Sample & container required||Serum (red top)|
|Sample volume||0.5 mL|
|Transport storage||Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis. Sample can be sent by first class post.|
|Turnaround time||10 days|
Grossly haemolysed samples are unsuitable for this assay.