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5α Dihydrotestosterone (5α DHT)

Category Biochemistry >> Endocrinology
Test background

5α Dihydrotestosterone (5α-DHT) is the most potent androgenic steroid and is the main intracellular androgen. In target tissues such as the prostate, seminal vesicles and skin, testosterone is reduced to 5α-DHT by the enzyme 5a-reductase.

Clinicial Indications

Its measurement (and the ratio of DHT to testosterone) is useful to identify end organ insensitivity to androgens due to 5α-reductase deficiency. This can be done in a random sample or in response to an hCG stimulation test.

Reference range

Females up to 1 nmol/L; Males 1 – 3 nmol/L

Sample & container required Serum (red top, plain tube) or plasma
Sample volume 0.5 mL
Transport storage Stable at 2-8°C for 24 hours. Please freeze pending dispatch for analysis. Send to lab frozen.
Turnaround time 4 weeks
Notes

Grossly haemolysed samples are unsuitable for this assay.