5α Dihydrotestosterone (5α DHT)
|Category||Biochemistry >> Endocrinology|
5α Dihydrotestosterone (5α-DHT) is the most potent androgenic steroid and is the main intracellular androgen. In target tissues such as the prostate, seminal vesicles and skin, testosterone is reduced to 5α-DHT by the enzyme 5a-reductase.
Its measurement (and the ratio of DHT to testosterone) is useful to identify end organ insensitivity to androgens due to 5Î±-reductase deficiency. This can be done in a random sample or in response to an hCG stimulation test.
Females up to <0.4 nmol/L;
Males 0.3 – 1.9 nmol/L
|Sample & container required||Serum (red top, plain tube)|
|Sample volume||0.5 mL|
|Transport storage||Stable at 2-8°C for 24 hours. Please freeze pending dispatch for analysis. Send to lab frozen.|
|Turnaround time||4 weeks|
Grossly haemolysed samples are unsuitable for this assay.