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Alkaline phosphatase (ALP)

Category Biochemistry
Test background

ALP is typically ubiquitous but predominates in the liver, bile ducts, bone and intestinal tissues. Leakage into the vasculature correlates with increased ALP turnover secondary to organ/tissue damage or increased production as a consequence of growth cycles, pregnancy or metastasis.

Clinical Indications

Bone pain, suspected liver impairment
Differential diagnosis: liver vs. bone causes (see ALP isoenzymes) consider also GGT

Reference range


Adult 30-130 IU/L
Less than 1 year 150-500 IU/L
1-5 years 150-770 IU/L
6-10 years 135-540 IU/L
Male 11-14 years 90-550 IU/L
Female 11-14 years 50-415 IU/L
Male 15-20 years 60-370 IU/L
Female 15-20 years 50-175 IU/L
Sample & container required SST (gold top)
Sample volume 0.5 mL
Turnaround time 1 day