Skip to main content

Please note that this is a beta version of our website. Should you encounter any bugs, glitches, lack of functionality or other problems on the website, please let us know immediately so we can rectify these accordingly. Your help in this regard is greatly appreciated! You can email us.

Login to North West London Pathology – consumables service

If you need a new account or you have a query about your order, please telephone the pathology call centre on 0203 313 5353.

If you have forgotten your password you can reset this yourself. Please click here if you have forgotten your password.

Results Line and Enquiries

0203 313 5353

Alpha-1-antitrypsin (A1AT)

Category Biochemistry >> Proteins
Test background

Familial A1AT deficiency leads to predominantly unrestricted proliferation of neutrophil-mediated elastase in the tissues of the lung, causing extensive collateral damage and subsequent emphysema-like symptoms in adults. Alternatively, neonatal accumulation of dysfunctional A1AT in the liver causes the production of abnormal polymers that damage the surrounding tissues of the liver.

Clinicial Indications

Unexplained liver cirrhosis in juveniles (and rarely adults) Suspected early-onset emphysema (juveniles/adults) or emphysema with or without family history Observed deficiency as seen on routine serum electrophoresis

Reference range

 

Adult 1.1-2.1 g/L
Newborn 0.9-2.2 g/L
Less than 6 months 0.8-1.8 g/L
6 months-1 year 1.1-2.0 g/L
1-5 years 1.1-2.2 g/L
5-10 years 1.4-2.3 g/L
10-15 years 1.2-2.0 g/L
Sample & container required Serum (red top) or SST (gold top)
Sample volume 0.5 mL
Transport storage Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis.
Sample can be sent by first class post.
Turnaround time 1 week
Notes

Grossly haemolysed samples are unsuitable for this assay.