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Angiotensin converting enzyme (ACE)

Category Biochemistry
Test background

Increased amounts of ACE often correlate to the presence of granulomas secondary to sarcoidosis, an idiopathic condition that often affects the lungs but may also affect the eyes, skin, nerves, liver and heart. About 50-80 % of patients with active sarcoidosis will have elevated levels of ACE.

Clinical Indications

Presentation of granulomas, a chronic cough or SOB, red watery eyes and/or joint pain.
NB ACE activity will be suppressed in those on ACE inhibitors

Reference range

 

19 years+ 20 – 70 U/L
Plus a range for less than 19y 29 – 112 U/L
Sample & container required SST (gold top) (NB EDTA inhibits ACE activity)
Sample volume 0.5 mL
Turnaround time SST: 1 day