Anti-Mϋllerian hormone (AMH)
| Category | Biochemistry >> Endocrinology | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Test background |
AMH can be used to assess ovarian reserve and has the advantage that, compared with FSH, inhibin A/B and ultrasound antral follicular count, levels are relatively unaffected by the menstrual cycle and typically show low intra-individual variation. With respect to Assisted Reproductive Technology (ART), AMH has been used to rationalise treatment regimes in controlled ovarian stimulation, thus reducing risk of hyper-stimulation (OHSS) and often reducing treatment costs. |
||||||||||
| Clinical Indications |
Assessment of appropriate stimulation regimes in ART Risk mitigation of OHSS in fertility treatment. Occasionally used in differential diagnosis and monitoring of ovarian tumours |
||||||||||
| Reference range | Adult males 10.2 – 82.8 pmol/L Adult females AMH levels decline with age and interpretation is therefore most appropriately made by the fertility specialist requesting the test and in conjunction with the antral follicle count.
|
||||||||||
| Sample & container required | Serum (red top) or (gold top) or lithium heparin plasma (green top) | ||||||||||
| Sample volume | 0.5 mL | ||||||||||
| Transport storage | Stable at 2-8°C for 24 hours. Please freeze pending dispatch for analysis. Send to lab frozen. |
||||||||||
| Turnaround time | 3 Days | ||||||||||
| Notes | Falsely low results may be obtained for this test due to biotin interference. Samples should not be taken from patients receiving therapy with high biotin doses (>5 mg/day) until at least 8 hours (ideally 2 days) following the last biotin administration. Grossly haemolysed samples are unsuitable for this assay. |
||||||||||