Apixaban
| Category | Haematology >> Specialised Coagulation Services | |||||||||
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| Test background |
Apixaban is a direct oral anticoagulant (DOAC) which exerts its anticoagulant effect through its ability to directly inhibit Coagulation Factor X. Plasma Apixaban levels are measured in mass concentration by chromogenic anti-Xa assay using drug-specific calibrators. |
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| Clinical Indications |
Recommended as an option for (NICE Guidelines 2016 – KTT16) • Prevention of VTE after elective hip or knee replacement DOAC monitoring is not generally required; however measurement may be useful where clearance is compromised or where patients are actively bleeding. |
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| Reference range | BCSH Guidelines (2014) Measurement of non-coumarin anticoagulants and their effects on tests of Haemostasis:
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| Sample & container required | 4.5 mL sodium citrate (pale blue top) adults 1.8 mL sodium citrate (pale blue top) paediatrics | |||||||||
| Turnaround time | <24 hours (core hours) | |||||||||
| Notes | Please Note: Samples will be rejected if under/over-filled, clotted or haemolysed |