Apolipoprotein A1 (Apo A1)
| Category | Biochemistry >> Proteins | ||||
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| Test background |
Apo A1 constitutes the major component of high density lipoprotein (HDL). Apo A1 is an activator of the enzyme lecithin:cholesterol acyltransferase and removes free cholesterol from extrahepatic tissues. Apo A1 concentrations correlate with high density lipoprotein cholesterol and thus low levels are a risk factor for coronary artery disease. Rarely, very low levels are seen in hereditary deficiency of LPA1. |
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| Clinical Indications |
Patients with a personal or family history of high concentrations of lipids and/or premature coronary heart disease Determine cause of high lipid concentrations with suspicion of a deficiency Used with Apo B to check ratio for coronary heart disease risk To monitor effectiveness of changes to lipid-lowering treatment or lifestyle changes |
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| Reference range |
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| Sample & container required | SST (gold top) or serum (red top) | ||||
| Sample volume | 0.5 mL | ||||
| Transport storage | Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis Sample can be sent by first class post. |
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| Turnaround time | 1 week | ||||
| Notes | Grossly haemolysed samples are unsuitable for this assay. |