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Apolipoprotein B (Apo B)

Category Biochemistry >> Proteins
Test background

One molecule of Apo B lies at the core of the VLDL moiety from which the enzyme lipoprotein lipase progressively removes triglycerides to form LDL. Measurement of Apo B facilitates a stratification of risk for the development of atherosclerotic heart disease in a manner analogous to that of LDL calculation, but not fraught with the same complications, eg. hypertriglyceridaemia hampers indirect inference of LDL from HDL/triglyceride assay.

Clinicial Indications

Suspected hyperlipidaemia/hyperlipidaemia Family history of cardiovascular heart disease Unreliable LDL calculation, ie. consistent hypertriglyceridaemia Investigations of the suspected inborn error of metabolism Bassen-Kornzweig syndrome (Apo B deficiency: symptoms include diarrhoea, failure to thrive, neurological disorders and steatorrhoea)

Reference range

 

Male 0.41 – 1.06 g/L
Female 0.47 – 0.99 g/L
Sample & container required SST (gold top) or serum (red top)
Sample volume 0.5 mL
Transport storage Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis.
Sample can be sent by first class post.
Turnaround time 1 week
Notes

Grossly haemolysed samples are unsuitable for this assay.