Apolipoprotein B (Apo B)
|Biochemistry >> Proteins
One molecule of Apo B lies at the core of the VLDL moiety from which the enzyme lipoprotein lipase progressively removes triglycerides to form LDL. Measurement of Apo B facilitates a stratification of risk for the development of atherosclerotic heart disease in a manner analogous to that of LDL calculation, but not fraught with the same complications, eg. hypertriglyceridaemia hampers indirect inference of LDL from HDL/triglyceride assay.
Suspected hyperlipidaemia/hyperlipidaemia Family history of cardiovascular heart disease Unreliable LDL calculation, ie. consistent hypertriglyceridaemia Investigations of the suspected inborn error of metabolism Bassen-Kornzweig syndrome (Apo B deficiency: symptoms include diarrhoea, failure to thrive, neurological disorders and steatorrhoea)
|Sample & container required
|SST (gold top) or serum (red top)
|Stable at 2-8°C for 72 hours. Please freeze pending dispatch for analysis.
Sample can be sent by first class post.
Grossly haemolysed samples are unsuitable for this assay.