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Bence-Jones protein (BJP)

Category Biochemistry >> Proteins
Test background

BJP is a paraprotein immunoglobulin free kappa or lambda light chain produced by neoplastic plasma cells. Light chains can be immunoglobulin fragments or single homogenous immunoglobulins. They are found in urine as they are small and hence easily cleared by the kidneys.

Clinicial Indications

A full myelomatosis screen must include a urine sample for BJP as it is the only detectable paraprotein in approximately 20 % of all such cases AL amyloidosis

Reference range

Qualitative test (positive/negative)

Sample & container required Random urine or 24 hour urine collection
Sample volume Random urine: 5 mLor 24 hour urine collection
Transport storage Please freeze pending dispatch for analysis. Sample can be sent by first class post.
Turnaround time 1 week
Notes

BJP will not be observed in non-secretory forms of multiple myeloma.

Acidified samples are unsuitable for this assay.