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Cortisol binding globulin

Category Biochemistry >> Endocrinology
Test background

CBG is the major binding protein for cortisol, with a smaller amount bound to albumin, and transports cortisol in the blood in an inactive form. Elevated CBG levels are seen in pregnancy and on oral contraceptive or oestrogen treatment. Low CBG levels may be observed in hyperinsulinaemic states, nephotic syndrome and chronic liver disease.

Clinical Indications

Interpretation of dynamic function tests of the HPA axis
Investigation of abnormal unexplained cortisol concentrations.

Reference range


Adult male 27.1-52.3 mg/L
Adult female 31.0-53.4 mg/L
Sample & container required Serum
Sample volume 0.5 mL
Transport storage Stable at 2-8°C for 48 hours. Please freeze pending dispatch for analysis.
Send to lab frozen.
Turnaround time 6 weeks

Mainly used for research purposes.

Grossly haemolysed samples are unsuitable for this assay.