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Cortisol (urine)

Category Biochemistry >> Endocrinology
Test background

Cortisol is secreted in a diurnal pattern with peak values occurring in the early morning. Random serum cortisol may be difficult to interpret. The diurnal rhythm may be disrupted or lost in Cushing's syndrome. Free cortisol measured in a 24 hour urine collection may be a more useful diagnostic tool in some patients.

Clinicial Indications

Most specific diagnostic indicator of Cushing's syndrome Differential diagnosis of phaeochromocytoma and Conn's syndrome

Reference range

50-270 nmol/L

Sample & container required 24 hour urine collection
Sample volume 1 mL
Sample collection

Please include time and volume for the 24 hour collection.

Transport storage Stable at 2-8°C for 24 hours. Please freeze pending dispatch for analysis. Can be sent by first class post.
Turnaround time 2 weeks
Notes

Acidified samples are unsuitable for this assay.