Cryoglobulins
| Category | Biochemistry >> Proteins |
|---|---|
| Test background |
Cryoglobulins are proteins that become insoluble at less than -4°C. Cryoglobulinaemia can be associated with various diseases: Type I is most commonly encountered in patients with a plasma cell dyscrasia such as multiple myeloma or Waldenström’s macroglobulinaemia. Types II and III are strongly associated with infection by hepatitis C and some connective tissue autoimmune diseases. |
| Clinical Indications |
Presentation of: arthralgia and joint disease, acrocyanosis, purpura, paraesthesia and peripheral neuropathy or Raynaud’s phenomenon (paroxysmal vasospastic and subsequent vasodilatory sequelae affecting peripheral arterioles usually in the hands and feet; commonly seen in response to cold exposure). |
| Sample & container required | Serum (red top) and EDTA (lavender top) Samples must be maintained at 37 degrees C. Please contact the site Specimen Reception to arrange collection of pre-warmed tubes. Samples received at room temperature are unsuitable |
| Sample volume | 8 mL of each sample type |
| Turnaround time | 2 weeks |
| Notes | Contact the Duty Biochemist/ laboratory before collecting samples. |