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D-Dimer

Category Haematology >> Specialised Coagulation Services
Test background

D-dimer results are often used in conjunction with the Well's score (an index of clinical suspicion of venous thromboembolism) in determining the diagnostic probability of a VTE. A negative d-dimer result is indicative of a low probability of VTE, but a raised d-dimer result may be due to many other factors, eg. infection, inflammation and pregnancy, and so should not be used to confirm a VTE diagnosis in the absence of any other supporting evidence.

Clinicial Indications

Assessment of deep vein thrombosis (DVT)
Exclusion of pulmonary embolism (PE)
Assessment and monitoring of disseminated intravascular coagulation (DIC)

Reference range
D-Dimer (ng/mL FEU)
Adult (>16 years) <500
Paediatric (11-16 years) 160-390
Paediatric (6-10 years) 100-560
Paediatric (1-5 years) 90-530
Paediatric (Day 4 – 1 year) 110-420
Paediatric (Day 2 – Day 3) 580-2740
Paediatric (Day 0-Day 1) 410-2470
Sample & container required 2.7 mL sodium citrate (pale blue top) adults 1.8 mL sodium citrate (pale blue top) paediatrics
Turnaround time 4 hours
Notes

Adult Reference Range:

Note: The reference ranges for use on patients over the age of 16 years, has been locally verified in accordance with CLSI Guideline EP28-A3c through evaluation on representative normal individuals across the sites to reflect our patient population.

Data sourced via Stago from:
Monagle P. et al. Thromb Haemost 2006; 95: 362-372.
Summerhayes R. et al. J Thromb Haemost, 2007; 5, Supp 2: P-M-105.
Summerhayes R. et al. J Thromb Haemost, 2007; 5, Supp 2: P-S-397.

Paediatric Reference Range

Note: Due to the complexity of collecting blood samples for analysis on normal neonates and paediatric patients, the reference ranges for use on patients up to 16 years of age have been taken from published data, from a research study using comparable methodology and equipment as that currently employed in our organisation. Please contact the laboratory for coagulation paediatric ranges.

Data sourced via Stago from:
Monagle P. et al. Thromb Haemost 2006; 95: 362-372.
Summerhayes R. et al. J Thromb Haemost, 2007; 5, Supp 2: P-M-105.
Summerhayes R. et al. J Thromb Haemost, 2007; 5, Supp 2: P-S-397.