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Dabigatran

Category Haematology >> Specialised Coagulation Services
Test background

Dabigatran is a direct thrombin inhibitor (DTI) which exerts its anticoagulant effect through its ability to directly inhibit Thrombin. Plasma Dabigatran levels are measured in mass concentration by dilute thrombin time assay using drug-specific calibrators.

Clinicial Indications

Recommended as an option for (NICE Guidelines 2016 - KTT16)

Prevention of VTE after elective hip or knee replacement;
Treatment and secondary prevention of DVT and/or PE;
Prevention of stroke and systemic embolism in people with non-valvular AF;

Dabigatran monitoring is not generally required; however measurement may be useful where clearance is compromised or where patients are actively bleeding.

Reference range

BCSH Guidelines (2014) Measurement of non-coumarin anticoagulants and their effects on tests of Haemostasis:

Dose Peak Mean Trough Mean
Dabigatran
150 mg bd
0.18 ug/mL
(0.06 – 0.44)
0.09 ug/mL
(0.03 – 0.23)
Sample & container required 4.5 mL sodium citrate (pale blue top) adults 1.8 mL sodium citrate (pale blue top) paediatrics
Turnaround time <24 hours (core hours)
Notes

Please Note: Samples will be rejected if under/over-filled, clotted or haemolysed