Donath-Lansteiner test (for paroxysmal cold haemoglobinuria)
Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by cold-reacting immunoglobulins. It primarily affects children and tends to cause quite severe, but transient, disease.
Presence of a biphasic antibody that binds to the red cells in the cold and lyses the red cell at 37 °C.
|Sample & container required||EDTA (lavender top)|
|Sample volume||4 mL for paediatrics 6 mL for adults|
|Turnaround time||Dependent on clinical requirement. Contact the laboratory to discuss further.|
This test is referred to the NHS Blood and Transplant service