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Donath-Lansteiner test (for paroxysmal cold haemoglobinuria)

Category Blood Transfusion
Test background

Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by cold-reacting immunoglobulins. It primarily affects children and tends to cause quite severe, but transient, disease.

Clinical Indications

Presence of a biphasic antibody that binds to the red cells in the cold and lyses the red cell at 37 °C.

Reference range

Not applicable

Sample & container required EDTA (lavender top)
Sample volume 4 mL for paediatrics 6 mL for adults
Turnaround time Dependent on clinical requirement. Contact the laboratory to discuss further.

This test is referred to the NHS Blood and Transplant service