Skip to main content

Please note that this is a beta version of our website. Should you encounter any bugs, glitches, lack of functionality or other problems on the website, please let us know immediately so we can rectify these accordingly. Your help in this regard is greatly appreciated! You can email us.

Login to North West London Pathology – consumables service

If you need a new account or you have a query about your order, please telephone the pathology call centre on 0203 313 5353.

If you have forgotten your password you can reset this yourself. Please click here if you have forgotten your password.

Results Line and Enquiries

0203 313 5353

Donath-Lansteiner test (for paroxysmal cold haemoglobinuria)

Category Blood Transfusion
Test background

Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by cold-reacting immunoglobulins. It primarily affects children and tends to cause quite severe, but transient, disease.

Clinicial Indications

Presence of a biphasic antibody that binds to the red cells in the cold and lyses the red cell at 37 °C.

Reference range

Not applicable

Sample & container required EDTA (lavender top)
Sample volume 4 mL for paediatrics 6 mL for adults
Turnaround time Dependent on clinical requirement. Contact the laboratory to discuss further.

This test is referred to the NHS Blood and Transplant service