Haemoglobin H inclusion bodies
Haemoglobin H and other unstable haemoglobins readily denature under oxidative stress to form intracellular inclusion bodies. Hb H bodies are looked for in patients suspected of having alpha thalassaemia trait, Hb H disease or an unstable haemoglobin. The Hb H inclusion bodies assay is used to confirm the presence of variants in haemoglobinopathy investigations.
Reflexed following haemoglobinopathy screens by Haematology medical or laboratory staff only.
|Sample & container required||4 mL EDTA (lavender top) adults; 0.5 mL EDTA (lavender top) paediatrics|
|Sample volume||0.5 mL adult tube; 0.2 mL paediatric tube|
|Turnaround time||1-3 days depending on the day of arrival|