Haemoglobin H inclusion bodies
| Category | Haematology |
|---|---|
| Test background |
Haemoglobin H and other unstable haemoglobins readily denature under oxidative stress to form intracellular inclusion bodies. Hb H bodies are looked for in patients suspected of having alpha thalassaemia trait, Hb H disease or an unstable haemoglobin. The Hb H inclusion bodies assay is used to confirm the presence of variants in haemoglobinopathy investigations. |
| Clinical Indications |
Reflexed following haemoglobinopathy screens by Haematology medical or laboratory staff only. |
| Sample & container required | 4 mL EDTA (lavender top) adults; 0.5 mL EDTA (lavender top) paediatrics |
| Sample volume | 0.5 mL adult tube; 0.2 mL paediatric tube |
| Turnaround time | 1-3 days depending on the day of arrival |